I heartily agree with the Indian food and 24-hour diner suggestions (esp. if there is late-night pie).
I've always thought that Short North would be the perfect spot for an izakaya (Japanese tapas--not sushi, but cooked things) or a ramen house. I don't expect Momofuku; it would just be nice to have a place that filled the niche of tasty asian street foods.
On a related note (although I don't envision one in SN), wouldn't it be nice to have a Hawaiian BBQ joint around town? Mmmm...kahlua pork and poke.